Create a figure of the TGF-β/SMAD signaling pathway: TGF-β ligand binding to Type II receptor (TβRII), Type I receptor (TβRI/ALK5) recruitment and transphosphorylation, R-SMAD (SMAD2/3) C-terminal phosphorylation, complex formation with Co-SMAD (SMAD4), nuclear translocation, interaction with co-activators (p300/CBP) and co-repressors (Ski/SnoN), transcription of target genes. Include I-SMAD (SMAD7) negative feedback and SMURF-mediated receptor degradation.
