Create a figure of the JAK-STAT signaling pathway: cytokine receptor dimerization upon ligand binding, JAK1/JAK2/TYK2 trans-phosphorylation, STAT (STAT1/3/5) recruitment via SH2 domain, tyrosine phosphorylation, STAT dimerization, nuclear translocation, DNA binding to GAS elements. Include three levels of negative regulation: SOCS proteins, protein tyrosine phosphatases (SHP-1/2), and PIAS. Show as a single continuous vertical flow diagram.
