Create a pharmaceutical drug development pipeline diagram: Target Discovery (genomics, proteomics) → Hit Identification (HTS, virtual screening) → Hit-to-Lead (SAR optimization) → Lead Optimization (ADMET, selectivity) → Preclinical (in vitro toxicology, rodent/primate PK, GLP studies) → IND Filing → Phase I (safety, healthy volunteers, n=20-80) → Phase II (efficacy, dose-finding, n=100-300) → Phase III (confirmatory, randomized controlled, n=1000-3000) → NDA/BLA → Approval → Phase IV (post-market surveillance). Show timeline and attrition rates.
