Lipid Nanoparticle mRNA Delivery

Prompt

Quell-Prompt, der fuer diese Vorlage verwendet wurde.

Create a graphical abstract for a lipid nanoparticle mRNA delivery paper: ionizable lipid/DSPC/cholesterol/PEG-lipid self-assembly around mRNA cargo using microfluidic mixing, LNP characterization (DLS size ~80nm, PDI, encapsulation efficiency), intramuscular injection, cellular uptake via macropinocytosis, endosomal escape mediated by ionizable lipid protonation at low pH, mRNA release into cytoplasm, ribosomal translation of encoded antigen, MHC-I/II presentation, B cell antibody response and CD8+ T cell activation. Circular layout.

FigPad

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