Create a graphical abstract for an organoid-based drug screening paper: patient tumor biopsy, Lgr5+ stem cell isolation, 3D culture in Matrigel with defined growth factors (EGF, Noggin, R-spondin), organoid expansion over passages, genomic characterization (WES, RNA-seq) confirming parental tumor fidelity, high-throughput drug screening on 384-well plate, dose-response curves for multiple compounds, identification of personalized effective therapy, clinical correlation. Flow layout with data panels.
