Create a graphical abstract for a base editing paper: adenine base editor (ABE) architecture showing nCas9(D10A) fused to evolved TadA adenosine deaminase and sgRNA, R-loop formation at target locus, A-to-I (read as G) conversion on non-target strand within editing window (positions 4-8), nick on target strand promoting mismatch repair favoring edited strand, comparison with standard CRISPR nuclease (DSB-dependent) showing reduced indel frequency and higher product purity. Include sequencing chromatogram result.
