Create a figure of the Notch signaling pathway: Notch receptor structure (EGF-like repeats, NRR, transmembrane domain, NICD), Delta/Jagged ligand on adjacent cell, mechanical force-induced S2 cleavage by ADAM10, γ-secretase S3 cleavage releasing NICD, NICD nuclear translocation, displacement of co-repressor complex (SMRT/NCoR) from CSL/RBPJ, recruitment of MAML1 and co-activators, activation of HES and HEY gene families. Show cell-cell contact context.
